2-(Isopropylamino)-2-(3-methoxyphenyl)cyclohexanone (also known as 3-MeO-2′-Oxo-PCiPr and MXiPr) is a novel dissociative substance of the arylcyclohexylamine class. It is a structural analog of MXE.

The circumstances surrounding MXiPr's original discovery are not known and its synthesis has not documented in the scientific literature. MXiPr first appeared on the online research chemical market in late 2020 and was marketed as a legal substitute for ketamine or MXE. The initial batch reportedly smelled like plastic and was suspected of containing impurities.

Subjective effects are comparable to ketamine and include sedation, motor control loss, pain relief, internal hallucinations, conceptual thinking, euphoria, and dissociation. Early anecdotal reports suggest that MXiPr exhibits two plateaus. The first plateau occurs at doses around 5-20 mg and produces a two hour long experience resembling nitrous oxide. The second plateau at doses around 20-40+ mg giving an experience similar to a ketamine k-hole, with a warmer or "dreamier" afterglow. It is not known if higher plateaus exist, and some researchers have urged caution if experimenting with higher doses. There are reports of body load occurring for up to 2 days after a small dose.

Very little data exists about the pharmacological properties, metabolism, and toxicity of MXiPr, and it has a very brief history of human usage. Given the reports of impure batches, it is advised to purify this substance before use (please see this section for more details). It is strongly recommended to use harm reduction practices if using this substance.

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